CP15 Oxygenator Changeout

O2 changeoutSpace 1

CP15 Oxygenator Changeout



Is your oxygenator failing?  Mechanical considerations need to be evaluated before oxygenator changeout.

O2 Failure

  1. Is oxygen being delivered to the oxygenator?
  2. Is the gas path obstructed?
  3. Is the gas connected to the correct ort?
  4. Are FiO2 and gas flow appropriate?

Patient considerations need to be evaluated

  1. Is the hematocrit adequate?
  2. What is the temperature?
  3. Is blood flow adequate?
  4. Are anesthesia and relaxant levels adequate?


Calculate O2 transfer of your oxygenator.

(arterial O2 content – venous O2 content) x (10) x (flow in LPM)

Art. Content= [9ven. Sat.%) x (1.34ml O2)x(Hgb gm %)]+[(PaO2)(.003)]

Ven. Content=[(ven.sat.%)(1.34ml O2)(Hgb gm %)]+[(PvO2)(.003)]

Maximum Value = 360ml/min @ blood flow 6L/min

Gas flow 15L/min

Blood temp 37*C

Hemoglobin 12g/dl


  1. oxygenator
  2. tubing clamps – 4
  3. 400 ml of prime solution
  4. sterile scissors


Prepare to change out the oxygenator by getting any necessary extras into the room, including additional perfusionists, oxygenators, clamps, sterile scissors, etc.  Notify the surgical team of your intentions and discuss your plans.  If possible, terminate cardiopulmonary bypass (CPB) and remind anesthesia to ventilate.  If changeout during bypass is unavoidable, then the following protocol should be observed.  Turn off water lines and disconnect from oxygenator.  Prep lines for sterile severance (alcohol).  Remove new oxygenator from package.  Come off bypass and clamp the arterial and venous lines to the patient and open the AV bridge.  Clamp out the arterial filter and/or open the filter bypass.  Double clamp all inlets and outlets of the oxygenator where you have previously prepped.  Using sterile scissors, cut inlet and outlet tubings and remove the failed oxygenator.  Insert new oxygenator into circuit and deair through the bridge.  Replace oxygen delivery line to air/O2 inlet on new oxygenator.  Open the arterial filter and clamp/close the arterial filter bypass while recirculating.  Deair filter.  Come off recirculation and clamp the AV bridge.  Reinitiate CPB as soon as possible.  Reconnect water lines and open valves.  Reuse checklist to confirm adequate reinitiation of CPB.

Space 1


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s